Regulatory Cluster
489 ingredients
Cosmetic Ingredients Flagged as Endocrine Disruptors
The term "endocrine disruptor" refers to exogenous substances that interfere with hormone systems and may produce adverse developmental, reproductive, neurological, or immune effects. The WHO/IPCS definition from 2002 remains the widely cited scientific baseline. The European Commission has adopted scientific criteria for identifying endocrine disruptors in several regulatory frameworks and continues to review candidate substances for cosmetic-specific screening under Regulation 1223/2009. Multiple public lists track suspected or confirmed endocrine disruptors: The Endocrine Disruption Exchange (TEDX) database, the Danish SIN (Substitute It Now) list, and national/supranational regulatory flag lists. This cluster lists cosmetic ingredients with documented endocrine disruptor classifications from these public sources.
Functional Categories
Skin Conditioning Ingredients
Humectants in Cosmetics
Emollient Ingredients in Cosmetics
Antioxidants in Cosmetics
Surfactants in Cosmetics
Emulsifiers in Cosmetics
Fragrance Ingredients in Cosmetics
Cosmetic Colorants
Cosmetic Preservatives
UV Filters & Sunscreen Ingredients
Hair Conditioning Ingredients
Rheology Modifiers & Thickeners
Active Cosmetic Ingredients
Plant Extracts & Botanical Ingredients
Regulatory Clusters
Cosmetic Ingredients Flagged as Endocrine Disruptors
Cosmetic Ingredients Listed Under California Proposition 65
Cosmetic Ingredients with SCCS Safety Opinions
Cosmetic Ingredients with CIR Expert Panel Conclusions
Cosmetic Ingredients with GHS Hazard Classification
Cosmetic Ingredients with NOAEL Toxicological Data
Cosmetic Ingredients Banned or Restricted Globally
Cosmetic Ingredients with Sensitization Data
Cosmetic Ingredients with Dermal Absorption Data
Cosmetic Ingredients Restricted Under EU Regulation 1223/2009
Browse A-Z
| Ingredient | Safety | ED Category |
|---|---|---|
| 1,2,4-Trihydroxybenzene | POOR | Biogenic compound, Byproduct/Intermediate/Reactant,… |
| 1,6-Hexanediamine | POOR | Byproduct/Intermediate/Reactant, Unconventional Oil and Gas |
| 1-Naphthol | MODERATE | Byproduct/Intermediate/Reactant, Household product ingredient, Industrial… |
| 2,7-Naphthalenediol | MODERATE | Byproduct/Intermediate/Reactant, Personal care product/Cosmetic ingredient |
| 2-BROMO-2-NITROPROPANE-1,3-DIOL | MODERATE | Antimicrobial, Household product ingredient, Industrial additive,… |
| 2-Bromo-2-Nitropropane-1,3-Diol (Bronopol) | MODERATE | Antimicrobial, Household product ingredient, Industrial additive,… |
| 2-Ethoxyethanol | POOR | Byproduct/Intermediate/Reactant, Household product ingredient, Industrial… |
| 2-Ethylhexanol | GOOD | Antimicrobial, Byproduct/Intermediate/Reactant, Household product ingredient,… |
| 2-Methylresorcinol | MODERATE | Household product ingredient, Personal care product/Cosmetic ingredient |
| 2-Methylresorcinol ⭐ (Most extensively assessed) | MODERATE | Household product ingredient, Personal care product/Cosmetic ingredient |
| 2-NAPHTHOL | MODERATE | Antimicrobial, Byproduct/Intermediate/Reactant, Industrial additive,… |
| 2-Naphthol (β-Naphthol) 🔴 | POOR | Antimicrobial, Byproduct/Intermediate/Reactant, Industrial additive,… |
| 3-Benzylidene Camphor | POOR | Household product ingredient, Medical/Veterinary/Research, Personal care… |
| 3-Ethylphenol | MODERATE | Byproduct/Intermediate/Reactant, Pesticide ingredient |
| 3-Nitro-P-Cresol | MODERATE | Byproduct/Intermediate/Reactant, Metabolite/Degradate |
| 4,4'-ISOPROPYLIDENEDIPHENOL | MODERATE | Byproduct/Intermediate/Reactant, Plastic/Rubber, Unconventional Oil and Gas |
| 4,4'-Isopropylidenediphenol (Bisphenol A / BPA) | POOR | Byproduct/Intermediate/Reactant, Plastic/Rubber, Unconventional Oil and Gas |
| 4-Ethylphenol | MODERATE | Byproduct/Intermediate/Reactant, Food additives and contact material,… |
| 4-Hydroxybenzoic Acid | EXCELLENT | Biogenic compound, Byproduct/Intermediate/Reactant, Food additives and contact… |
| 4-Phenylpropylpyridine | GOOD | - |
| 4-T-Butylbenzoic Acid | POOR | Byproduct/Intermediate/Reactant, Household product ingredient, Industrial… |
| 4-T-Butylcyclohexanol | GOOD | Byproduct/Intermediate/Reactant, Food additives and contact material, Household… |
| ACETALDEHYDE | MODERATE | Byproduct/Intermediate/Reactant, Food additives and contact material, Household… |
| ACETONYLACETONE | GOOD | Byproduct/Intermediate/Reactant, Medical/Veterinary/Research, Metal/Metallurgy,… |
| ACETYL HEXAMETHYL INDAN | MODERATE | Household product ingredient, Personal care product/Cosmetic ingredient,… |
| AVOBENZONE (BUTYL METHOXYDIBENZOYLMETHANE) | GOOD | - |
| Acetone | MODERATE | Byproduct/Intermediate/Reactant, Household product ingredient, Personal care… |
| Acetonylacetone (2,5-Hexanedione) | POOR | Byproduct/Intermediate/Reactant, Medical/Veterinary/Research, Metal/Metallurgy,… |
| Acetyl Hexamethyl Tetralin (AHTN) | MODERATE | fragrance |
| Acid Red 51 (Erythrosine) | MODERATE | Food additives and contact material, Medical/Veterinary/Research |
| Alcohol | GOOD | Byproduct/Intermediate/Reactant, Household product ingredient,… |
| Alcohol Denat | MODERATE | Byproduct/Intermediate/Reactant, Household product ingredient,… |
| Alpha-Arbutin | GOOD | other |
| Alpha-Isomethyl Ionone | GOOD | fragrance |
| Aluminum Chloride | MODERATE | heavy metal |
| Aluminum Chlorohydrate | GOOD | heavy metal |
| Aluminum Powder (CI 77000) | GOOD | Byproduct/Intermediate/Reactant, Food additives and contact material, Household… |
| Amiloxate (Isoamyl p-Methoxycinnamate) | GOOD | - |
| Ammonia | MODERATE | Biogenic compound, Byproduct/Intermediate/Reactant, Household product… |
| Ammonium Chloride | GOOD | Flame retardant, Food additives and contact material, Household product… |
| Ammonium Lauryl Sulfate | GOOD | surfactant |
| Ammonium Nitrate | POOR | Byproduct/Intermediate/Reactant, Household product ingredient, Industrial… |
| Ammonium Persulfate | POOR | other |
| Ammonium Sulfate | GOOD | Byproduct/Intermediate/Reactant, Flame retardant, Food additives and contact… |
| Amyl Cinnamal | MODERATE | fragrance |
| Anisic Acid | GOOD | Food additives and contact material, Medical/Veterinary/Research, Personal care… |
| Apigenin | GOOD | Biogenic compound, Medical/Veterinary/Research, Personal care product/Cosmetic… |
| Arbutin | GOOD | other |
| Arbutin (Alpha-Arbutin and Beta-Arbutin) | GOOD | other |
| Avobenzone | GOOD | - |
| Azelaic Acid | EXCELLENT | Byproduct/Intermediate/Reactant, Medical/Veterinary/Research, Personal care… |
| BENZALDEHYDE | GOOD | Byproduct/Intermediate/Reactant, Food additives and contact material, Personal… |
| BENZOPHENONE-3 | MODERATE | Personal care product/Cosmetic ingredient, Pesticide ingredient, Plastic/Rubber |
| BHA | GOOD | Food additives and contact material, Industrial additive, Personal care… |
| BHA (Butylated Hydroxyanisole) | MODERATE | Food additives and contact material, Industrial additive, Personal care… |
| BHT | GOOD | Food additives and contact material, Household product ingredient, Industrial… |
| BHT (Butylated Hydroxytoluene) | GOOD | Food additives and contact material, Household product ingredient, Industrial… |
| BHT (Butylated Hydroxytoluene) | MODERATE | Food additives and contact material, Household product ingredient, Industrial… |
| BUTYLPHENYL METHYLPROPIONAL | MODERATE | - |
| Balm Mint Leaf Extract | GOOD | Biogenic compound, Food additives and contact material,… |
| Barium Chloride | POOR | Byproduct/Intermediate/Reactant, Household product ingredient,… |
| Bemotrizinol | EXCELLENT | UV filter |
| Benzalkonium Chloride | MODERATE | preservative |
| Benzoic Acid | GOOD | Byproduct/Intermediate/Reactant, Household product ingredient,… |
| Benzophenone-2 | POOR | Food additives and contact material, Household product ingredient, Personal… |
| Benzophenone-3 (Oxybenzone) | MODERATE | Personal care product/Cosmetic ingredient, Pesticide ingredient, Plastic/Rubber |
| Benzophenone-5 | GOOD | UV filter |
| Benzophenone-8 | MODERATE | Food additives and contact material, Industrial additive, Personal care… |
| Benzyl Alcohol | MODERATE | preservative |
| Benzyl Benzoate | MODERATE | fragrance |
| Benzyl Salicylate | MODERATE | Food additives and contact material, Household product ingredient,… |
| Benzylparaben | POOR | Antimicrobial, Medical/Veterinary/Research, Personal care product/Cosmetic… |
| Beta-Arbutin | GOOD | other |
| Beta-Carotene | EXCELLENT | Biogenic compound, Food additives and contact material, Household product… |
| Biochanin A | MODERATE | - |
| Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine | GOOD | UV filter |
| Bischofite Magnesium Chloride | EXCELLENT | Byproduct/Intermediate/Reactant, Flame retardant, Household product ingredient,… |
| Bronopol | MODERATE | Antimicrobial, Household product ingredient, Industrial additive,… |
| Butadiene | POOR | Byproduct/Intermediate/Reactant, Food additives and contact material,… |
| Butoxydiglycol | MODERATE | Byproduct/Intermediate/Reactant, Household product ingredient, Industrial… |
| Butoxyethanol | MODERATE | Household product ingredient, Industrial additive, Pesticide ingredient,… |
| Butyl Benzyl Phthalate | POOR | Byproduct/Intermediate/Reactant, Household product ingredient, Industrial… |
| Butyl Benzyl Phthalate (BBP) | POOR | Byproduct/Intermediate/Reactant, Household product ingredient, Industrial… |
| Butyl Methoxydibenzoylmethane | GOOD | - |
| Butyl PABA | POOR | - |
| Butyl Phthalyl Butyl Glycolate | MODERATE | Medical/Veterinary/Research, Plastic/Rubber |
| Butylated Hydroxyanisole | GOOD | Food additives and contact material, Industrial additive, Personal care… |
| Butylated Hydroxytoluene | GOOD | Food additives and contact material, Household product ingredient, Industrial… |
| Butylparaben | MODERATE | Antimicrobial, Food additives and contact material,… |
| Butylphenyl Methylpropional (Lilial) | POOR | - |
| CI 15985 | GOOD | Food additives and contact material, Industrial additive, Personal care… |
| CI 15985 Yellow 6 Lake | MODERATE | Food additives and contact material, Industrial additive, Personal care… |
| CI 42053 | GOOD | Food additives and contact material, Medical/Veterinary/Research, Personal care… |
| CI 45430 | MODERATE | Food additives and contact material, Medical/Veterinary/Research |
| CI 58000 | MODERATE | Biogenic compound, Byproduct/Intermediate/Reactant, Medical/Veterinary/Research |
| CI 75130 (Beta-Carotene) | EXCELLENT | Biogenic compound, Food additives and contact material, Household product… |
| CI 77000 (Aluminum) | GOOD | Byproduct/Intermediate/Reactant, Food additives and contact material, Household… |
| CI 77820 | MODERATE | Antimicrobial, Household product ingredient, Medical/Veterinary/Research,… |
| CI 77891 (Titanium Dioxide) | GOOD | Byproduct/Intermediate/Reactant, Food additives and contact material, Household… |
| CI 77947 (Zinc Oxide) | GOOD | Antimicrobial, Byproduct/Intermediate/Reactant, Flame retardant, Food additives… |
| CINNAMAL | MODERATE | Byproduct/Intermediate/Reactant, Food additives and contact material, Household… |
| Caffeine | GOOD | Biogenic compound, Food additives and contact material,… |
| Capric Acid | GOOD | Byproduct/Intermediate/Reactant, Food additives and contact material, Household… |
| Caprylic Acid | GOOD | Antimicrobial, Byproduct/Intermediate/Reactant, Flame retardant, Food additives… |
| Caprylic/Capric Triglyceride | EXCELLENT | other |
| Caprylic/Capric Triglyceride | EXCELLENT | other |
| Caprylyl Gallate | MODERATE | other |
| Captan | MODERATE | Household product ingredient, Personal care product/Cosmetic ingredient,… |
| Cashmeran | GOOD | Household product ingredient, Personal care product/Cosmetic ingredient,… |
| Cedrol | GOOD | fragrance |
| Celestolide | MODERATE | Household product ingredient, Personal care product/Cosmetic ingredient,… |
| Chlorhexidine | MODERATE | preservative |
| Chlorine Dioxide | POOR | Antimicrobial, Food additives and contact material, Household product… |
| Chloroacetamide | POOR | Antimicrobial, Byproduct/Intermediate/Reactant, Industrial additive, Personal… |
| Chlorothymol | MODERATE | Antimicrobial, Household product ingredient, Medical/Veterinary/Research,… |
| Chloroxylenol | GOOD | Antimicrobial, Household product ingredient, Personal care product/Cosmetic… |
| Chloroxylenol (PCMX) | GOOD | Antimicrobial, Household product ingredient, Personal care product/Cosmetic… |
| Chlorphenesin | GOOD | preservative |
| Chromium | MODERATE | Byproduct/Intermediate/Reactant, Household product ingredient,… |
| Chrysin | GOOD | - |
| Cinnamal (Cinnamaldehyde) | MODERATE | Byproduct/Intermediate/Reactant, Food additives and contact material, Household… |
| Cinnamyl Alcohol | MODERATE | fragrance |
| Citral | MODERATE | fragrance |
| Citronellol | MODERATE | fragrance |
| Clotrimazole | POOR | Antimicrobial, Medical/Veterinary/Research, Pesticide ingredient |
| Coal Tar | POOR | other |
| Cobalt Chloride | POOR | heavy metal |
| Cocamide DEA | GOOD | surfactant |
| Colloidal Silver | POOR | Antimicrobial, Household product ingredient, Medical/Veterinary/Research,… |
| Coumarin | MODERATE | fragrance |
| Cupric Acetate | POOR | Byproduct/Intermediate/Reactant, Household product ingredient,… |
| Cupric Chloride | MODERATE | Byproduct/Intermediate/Reactant, Food additives and contact material, Household… |
| Cyclohexanone | POOR | Byproduct/Intermediate/Reactant, Household product ingredient, Pesticide… |
| Cyclohexasiloxane | MODERATE | other |
| Cyclomethicone | MODERATE | Byproduct/Intermediate/Reactant, Industrial additive, Personal care… |
| Cyclopentasiloxane | MODERATE | Byproduct/Intermediate/Reactant, Industrial additive, Personal care… |
| Cyclotetrasiloxane | POOR | Byproduct/Intermediate/Reactant, Food additives and contact material, Household… |
| D-Limonene | MODERATE | fragrance |
| DIBROMOCYANOACETAMIDE | GOOD | Antimicrobial, Household product ingredient, Industrial additive,… |
| DIBUTYL PHTHALATE | MODERATE | Household product ingredient, Industrial additive, Personal care… |
| DICHLOROMETHANE | MODERATE | Byproduct/Intermediate/Reactant, Food additives and contact material, Household… |
| DIETHANOLAMINE | MODERATE | Byproduct/Intermediate/Reactant, Household product ingredient, Industrial… |
| DIETHYL PHTHALATE | GOOD | Household product ingredient, Personal care product/Cosmetic ingredient,… |
| DIETHYLHEXYL PHTHALATE | MODERATE | Household product ingredient, Industrial additive, Medical/Veterinary/Research,… |
| DIHYDRO PENTAMETHYLINDANONE | GOOD | Household product ingredient, Personal care product/Cosmetic ingredient,… |
| DISODIUM SELENITE | MODERATE | Byproduct/Intermediate/Reactant, Household product ingredient, Industrial… |
| DMDM Hydantoin | MODERATE | preservative |
| Daidzein | GOOD | Biogenic compound, Medical/Veterinary/Research |
| Dead Sea Salt | GOOD | Byproduct/Intermediate/Reactant, Food additives and contact material, Household… |
| Deltamethrin | POOR | Household product ingredient, Industrial additive, Medical/Veterinary/Research,… |
| Dibenzothiophene | POOR | Byproduct/Intermediate/Reactant, Medical/Veterinary/Research, Personal care… |
| Dibromocyanoacetamide (DBNPA) | POOR | Antimicrobial, Household product ingredient, Industrial additive,… |
| Dibutyl Adipate | EXCELLENT | Household product ingredient, Personal care product/Cosmetic ingredient,… |
| Dibutyl Phthalate (DBP) | POOR | Household product ingredient, Industrial additive, Personal care… |
| Dibutyl Phthalate (DBP) | POOR | Household product ingredient, Industrial additive, Personal care… |
| Dibutyl Sebacate | GOOD | other |
| Dichlorophene | POOR | Antimicrobial, Household product ingredient, Industrial additive,… |
| Didecyldimonium Chloride | MODERATE | Household product ingredient, Industrial additive, Medical/Veterinary/Research,… |
| Diethanolamine (DEA) | POOR | Byproduct/Intermediate/Reactant, Household product ingredient, Industrial… |
| Diethanolamine (restrictions) | GOOD | Byproduct/Intermediate/Reactant, Household product ingredient, Industrial… |
| Diethyl Adipate | GOOD | Byproduct/Intermediate/Reactant, Plastic/Rubber |
| Diethyl Phthalate (DEP) | MODERATE | Household product ingredient, Personal care product/Cosmetic ingredient,… |
| Diethylamine | POOR | Household product ingredient, Industrial additive, Medical/Veterinary/Research,… |
| Diethylamino Hydroxybenzoyl Hexyl Benzoate | GOOD | UV filter |
| Diethylene Glycol | POOR | Byproduct/Intermediate/Reactant, Household product ingredient, Industrial… |
| Diethylhexyl Adipate | GOOD | Food additives and contact material, Household product ingredient, Industrial… |
| Diethylhexyl Phthalate (DEHP) | POOR | Household product ingredient, Industrial additive, Medical/Veterinary/Research,… |
| Diethylhexyl Phthalate (DEHP) | POOR | Household product ingredient, Industrial additive, Medical/Veterinary/Research,… |
| Dihydro Pentamethylindanone (DPMI / Cashmeran) | MODERATE | Household product ingredient, Personal care product/Cosmetic ingredient,… |
| Dihydroquercetin | EXCELLENT | - |
| Dihydroxyacetone | GOOD | other |
| Dihydroxybiphenyl | POOR | Byproduct/Intermediate/Reactant, Food additives and contact material,… |
| Diisobutyl Adipate | EXCELLENT | - |
| Dimethyl Oxazolidine | MODERATE | - |
| Dimethyl Phthalate | MODERATE | Household product ingredient, Industrial additive, Personal care… |
| Diphenolic Acid | POOR | Byproduct/Intermediate/Reactant, Industrial additive,… |
| Dodecyl Gallate | GOOD | other |
| Drometrizole | GOOD | UV filter |
| Drometrizole Trisiloxane | GOOD | UV filter |
| Drometrizole Trisiloxane (Mexoryl XL) | MODERATE | UV filter |
| ETHYLHEXANOL | GOOD | Antimicrobial, Byproduct/Intermediate/Reactant, Household product ingredient,… |
| Ensulizole | MODERATE | UV filter |
| Enzacamene (4-Methylbenzylidene Camphor) | POOR | - |
| Epichlorohydrin | POOR | Byproduct/Intermediate/Reactant, Industrial additive, Pesticide ingredient,… |
| Erythrosin | POOR | Food additives and contact material, Medical/Veterinary/Research |
| Ethanol | MODERATE | Byproduct/Intermediate/Reactant, Household product ingredient,… |
| Ethoxyethanol (2-Ethoxyethanol) | POOR | Byproduct/Intermediate/Reactant, Household product ingredient, Industrial… |
| Ethoxyethanol Acetate | MODERATE | Byproduct/Intermediate/Reactant, Household product ingredient, Personal care… |
| Ethyl Salicylate | MODERATE | Food additives and contact material, Personal care product/Cosmetic ingredient |
| Ethylbenzene | POOR | Byproduct/Intermediate/Reactant, Household product ingredient, Industrial… |
| Ethylene Brassylate | EXCELLENT | fragrance |
| Ethylene Brassylate (Macrocycle) | EXCELLENT | fragrance |
| Ethylhexanol (2-Ethyl-1-hexanol) | MODERATE | Antimicrobial, Byproduct/Intermediate/Reactant, Household product ingredient,… |
| Ethylhexyl Dimethyl PABA | GOOD | Personal care product/Cosmetic ingredient, Pesticide ingredient |
| Ethylhexyl Methoxycinnamate | MODERATE | Personal care product/Cosmetic ingredient, Pesticide ingredient, Unconventional… |
| Ethylhexyl Salicylate | GOOD | - |
| Ethylhexyl Triazone | GOOD | UV filter |
| Ethylhexyl Triazone | GOOD | UV filter |
| Ethylparaben | GOOD | Antimicrobial, Food additives and contact material, Household product… |
| Ethylparaben | GOOD | Antimicrobial, Food additives and contact material, Household product… |
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