Cosmetic Ingredients with NOAEL Toxicological Data

The No Observed Adverse Effect Level (NOAEL) is the highest dose of a substance at which no statistically or biologically significant adverse effect is observed in a toxicological study. NOAEL values are the primary input to Margin of Safety (MoS) calculations under SCCS methodology: MoS = NOAEL ÷ SED, where SED is Systemic Exposure Dose. A MoS ≥ 100 is generally considered safe for cosmetic use. NOAEL values are aggregated from SCCS opinions, CIR expert panel reports, ECHA REACH registration dossiers, the EPA ToxValDB database, and the ILO/WHO International Chemical Safety Cards. This cluster lists cosmetic ingredients with NOAEL study data available in the Roots database, sorted by study count.