Regulatory Cluster 1268 ingredients

Cosmetic Ingredients with NOAEL Toxicological Data

The No Observed Adverse Effect Level (NOAEL) is the highest dose of a substance at which no statistically or biologically significant adverse effect is observed in a toxicological study. NOAEL values are the primary input to Margin of Safety (MoS) calculations under SCCS methodology: MoS = NOAEL ÷ SED, where SED is Systemic Exposure Dose. A MoS ≥ 100 is generally considered safe for cosmetic use. NOAEL values are aggregated from SCCS opinions, CIR expert panel reports, ECHA REACH registration dossiers, the EPA ToxValDB database, and the ILO/WHO International Chemical Safety Cards. This cluster lists cosmetic ingredients with NOAEL study data available in the Roots database, sorted by study count.

Functional Categories
Skin Conditioning Ingredients Humectants in Cosmetics Emollient Ingredients in Cosmetics Antioxidants in Cosmetics Surfactants in Cosmetics Emulsifiers in Cosmetics Fragrance Ingredients in Cosmetics Cosmetic Colorants Cosmetic Preservatives UV Filters & Sunscreen Ingredients Hair Conditioning Ingredients Rheology Modifiers & Thickeners Active Cosmetic Ingredients Plant Extracts & Botanical Ingredients
Regulatory Clusters
Cosmetic Ingredients Flagged as Endocrine Disruptors Cosmetic Ingredients Listed Under California Proposition 65 Cosmetic Ingredients with SCCS Safety Opinions Cosmetic Ingredients with CIR Expert Panel Conclusions Cosmetic Ingredients with GHS Hazard Classification Cosmetic Ingredients with NOAEL Toxicological Data Cosmetic Ingredients Banned or Restricted Globally Cosmetic Ingredients with Sensitization Data Cosmetic Ingredients with Dermal Absorption Data Cosmetic Ingredients Restricted Under EU Regulation 1223/2009
Browse A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #
Ingredient Safety Studies
Ethoxydiglycol GOOD 286
Ceratonia Siliqua Gum EXCELLENT 203
O-PHENYLPHENOL MODERATE 172
Triclocarban GOOD 160
Melamine POOR 158
Triclosan POOR 141
Benzophenone-3 (Oxybenzone) MODERATE 139
Oxybenzone POOR 139
BENZOPHENONE-3 MODERATE 139
Resorcinol Cosmetic MODERATE 126
Resorcinol MODERATE 126
Butylparaben MODERATE 120
Methyl Pyrrolidone MODERATE 105
Kojic Acid MODERATE 100
P-PHENYLENEDIAMINE MODERATE 99
Cannabidiol (CBD) GOOD 96
Cannabidiol – Derived from Extract or Tincture or Resin of Cannabis MODERATE 96
Tetrabromophenol Blue MODERATE 96
Polyaminopropyl Biguanide MODERATE 92
CI 42090 (Brilliant Blue FCF) GOOD 91
FD&C Blue No. 1 GOOD 91
FD&C Blue No. 1 (CI 42090) GOOD 91
Acid Blue 9 EXCELLENT 91
CI 42090 MODERATE 91
Melaleuca Alternifolia (Tea Tree) Leaf Oil GOOD 88
Tea Tree Oil MODERATE 88
Tea Tree Oil (Melaleuca Alternifolia Leaf Oil) GOOD 88
Hexyl Salicylate MODERATE 85
Ethyl Lauroyl Arginate HCl GOOD 84
Butoxyethanol MODERATE 84
O-Cresol POOR 83
Diethylamino Hydroxybenzoyl Hexyl Benzoate GOOD 80
Uvinul A Plus GOOD 80
Propylparaben MODERATE 76
Enzacamene (4-Methylbenzylidene Camphor) POOR 72
Beta-Carotene EXCELLENT 72
CI 75130 (Beta-Carotene) EXCELLENT 72
Toluene-2,5-Diamine MODERATE 72
CI 15985 Yellow 6 Lake MODERATE 71
Silver POOR 71
Colloidal Silver POOR 71
CI 15985 GOOD 71
CI 77820 MODERATE 71
HC Red No. 3 MODERATE 70
BUTYLPHENYL METHYLPROPIONAL MODERATE 68
Butylphenyl Methylpropional (Lilial) POOR 68
Aspartame GOOD 66
1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate MODERATE 64
Basic Red 51 MODERATE 64
Hydroxyethyl-p-Phenylenediamine Sulfate MODERATE 62
Arbutin GOOD 60
Arbutin (Alpha-Arbutin and Beta-Arbutin) GOOD 60
Beta-Arbutin GOOD 60
Basic Orange 31 MODERATE 60
Disperse Red 17 MODERATE 60
N,N'-BIS(2-HYDROXYETHYL)-2-NITRO-P-PHENYLENEDIAMINE GOOD 60
Methylparaben GOOD 58
BHA GOOD 56
Butylated Hydroxyanisole GOOD 56
BHA (Butylated Hydroxyanisole) MODERATE 56
Dimethyl Phthalate MODERATE 56
Glyoxal POOR 55
Laureth-30 MODERATE 55
Laureth-50 GOOD 55
Orange 4 (CI 15510) GOOD 53
Zinc Pyrithione MODERATE 53
Acid Orange 7 MODERATE 53
CI 15510 (D&C Orange No. 4 / Acid Orange 7) GOOD 53
2-Nitro-5-Glyceryl Methylaniline MODERATE 52
Alpha-Arbutin GOOD 52
Climbazole GOOD 52
DIHYDROXYINDOLE POOR 52
Thioglycolic Acid MODERATE 52
Salicylic Acid GOOD 49
Magnesium Coceth Sulfate MODERATE 48
PEG-15 Cocamine MODERATE 48
PEG-2 Cocamine MODERATE 48
PEG-20 COCAMINE GOOD 48
PEG-3 COCAMINE GOOD 48
PEG-5 COCAMINE GOOD 48
Polysorbate 20 GOOD 46
PEG-10 SORBITAN LAURATE GOOD 46
PEG-40 SORBITAN LAURATE GOOD 46
PEG-44 SORBITAN LAURATE GOOD 46
Polysorbate 21 GOOD 46
Benzethonium Chloride MODERATE 44
Genistein GOOD 44
Nano Zinc Oxide GOOD 44
Phenoxyethanol GOOD 44
Soy Isoflavones GOOD 44
Zinc Oxide EXCELLENT 44
CI 77947 (Zinc Oxide) GOOD 44
Lawsonia Inermis Callus Culture Extract MODERATE 44
Lawsonia Inermis Cera GOOD 44
Lawsonia Inermis Extract MODERATE 44
Lawsonia Inermis Leaf Extract MODERATE 44
Lawsonia Inermis Wax GOOD 44
Malonic Acid MODERATE 44
TETRAHYDROPYRANYLOXY PHENOL GOOD 44
Tetrahydropyranyloxy Phenol (Deoxyarbutin) MODERATE 44
Hydroxyethyl-2-Nitro-p-Toluidine MODERATE 43
2-Methylresorcinol MODERATE 42
2-Methylresorcinol ⭐ (Most extensively assessed) MODERATE 42
Glycerin EXCELLENT 42
1-Naphthol MODERATE 41
Hydrogen Peroxide MODERATE 41
2-Hydroxyethyl Picramic Acid GOOD 40
2,6-Dihydroxyethylaminotoluene GOOD 40
BHT (Butylated Hydroxytoluene) GOOD 40
Butylated Hydroxytoluene GOOD 40
Caffeine GOOD 40
Cetrimonium Chloride MODERATE 40
Propanediol EXCELLENT 40
BHT GOOD 40
BHT (Butylated Hydroxytoluene) MODERATE 40
Isobutoxypropanol MODERATE 40
Lawsone MODERATE 40
t-Butyl p-Cresol (BHT) GOOD 40
CI 16035 (Allura Red AC) MODERATE 38
Cetylpyridinium Chloride GOOD 38
CI 16035 GOOD 38
CURRY RED MODERATE 38
Curry Red (CI 16035) GOOD 38
Methyl Salicylate MODERATE 37
3-Benzylidene Camphor POOR 36
Cyclotetrasiloxane POOR 36
Homosalate MODERATE 36
Red 33 (CI 17200) GOOD 36
Acid Red 33 GOOD 36
Ammonium Silver Zinc Aluminum Silicate MODERATE 36
CI 17200 GOOD 36
HC Orange No. 2 MODERATE 36
Chloroacetamide POOR 35
Sodium Nitrite MODERATE 35
Methylisothiazolinone POOR 34
METHYLISOTHIAZOLINONE (MIT) GOOD 34
DIETHYL PHTHALATE GOOD 33
Diethyl Phthalate (DEP) MODERATE 33
N,N-BIS(2-HYDROXYETHYL)-P-PHENYLENEDIAMINE SULFATE MODERATE 33
2-Amino-4-Hydroxyethylaminoanisole MODERATE 32
4-Amino-3-Nitrophenol MODERATE 32
4-Nitro-O-Phenylenediamine MODERATE 32
Diethanolamine (restrictions) GOOD 32
Ethylhexyl Methoxycinnamate MODERATE 32
Ingredient compliance data extraction GOOD 32
Octinoxate MODERATE 32
Sodium Benzoate EXCELLENT 32
Acid Yellow 1 MODERATE 32
Basic Brown 16 POOR 32
Camphor Benzalkonium Methosulfate MODERATE 32
CI 10316 (Ext. D&C Yellow No. 7) MODERATE 32
DIETHANOLAMINE MODERATE 32
Diethanolamine (DEA) POOR 32
Disperse Violet 1 MODERATE 32
HC Orange No. 1 MODERATE 32
HC Red No. 18 MODERATE 32
HC Yellow No. 4 GOOD 32
TRIMETHYLBENZOYL DIPHENYLPHOSPHINE OXIDE GOOD 32
Trimethylbenzoyl Diphenylphosphine Oxide (TPO) MODERATE 32
Monoethanolamine (MEA) MODERATE 30
1,5-Naphthalenediol MODERATE 29
Benzisothiazolinone MODERATE 29
Titanium Dioxide EXCELLENT 29
CI 61570 MODERATE 29
CI 77891 (Titanium Dioxide) GOOD 29
HC Blue No. 2 GOOD 29
2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE MODERATE 28
2,7-Naphthalenediol MODERATE 28
3-Amino-2,4-Dichlorophenol MODERATE 28
4-Formyl-1-Methylquinolinium-P-Toluenesulfonate GOOD 28
Benzyl Salicylate MODERATE 28
Betaine EXCELLENT 28
CI 15850 Red 7 Lake GOOD 28
D&C Red No. 6 GOOD 28
D&C Red No. 6 (CI 15850) GOOD 28
Red 6 Lake (CI 15850) GOOD 28
TriAsorB MODERATE 28
Betaine EXCELLENT 28
Diammonium Phosphate GOOD 28
Diethylene Glycol POOR 28
HC Blue No. 17 MODERATE 28
HC Orange No. 6 MODERATE 28
HC RED NO. 1 POOR 28
HC Yellow No. 9 MODERATE 28
Hydroxyanthraquinoneaminopropyl Methyl Morpholinium Methosulfate MODERATE 28
Methylimidazoliumpropyl p-Phenylenediamine HCl MODERATE 28
Phenyl Methyl Pyrazolone GOOD 28
Pigment Red 57 GOOD 28
Hydroxyethyl-3,4-Methylenedioxyaniline HCl GOOD 27
Stannous Chloride MODERATE 27
Hydrolyzed Silica GOOD 26
Silica EXCELLENT 26
ACRYLAMIDE MODERATE 26
5-Amino-6-Chloro-o-Cresol MODERATE 25
Butoxydiglycol MODERATE 25
Hydroxyethoxy Aminopyrazolopyridine HCl MODERATE 25
P-AMINOPHENOL MODERATE 25
2-Methyl-1-Naphthol MODERATE 24
3-Amino-2,6-Dimethylphenol MODERATE 24
4-Chlororesorcinol MODERATE 24
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