Regulatory Cluster 200 ingredients

Cosmetic Ingredients Restricted Under EU Regulation 1223/2009

EU Regulation (EC) No 1223/2009 on cosmetic products operates on a positive-list approach. Annex II lists substances prohibited from use in cosmetic products. Annex III lists substances that may be used subject to concentration limits, product type restrictions, warning statements, or other conditions. Annex IV lists permitted colorants, Annex V lists permitted preservatives, and Annex VI lists permitted UV filters. The Annex lists are maintained by the European Commission and amended through Commission Regulations based on SCCS opinions. Recent Annex amendments include retinol concentration restrictions, homosalate concentration caps in face products under SCCS opinion SCCS/1622/20, and a substantial expansion of the fragrance allergen declaration list under Regulation (EU) 2023/1545. This cluster lists cosmetic ingredients with documented EU Annex II or Annex III restrictions.

Functional Categories
Skin Conditioning Ingredients Humectants in Cosmetics Emollient Ingredients in Cosmetics Antioxidants in Cosmetics Surfactants in Cosmetics Emulsifiers in Cosmetics Fragrance Ingredients in Cosmetics Cosmetic Colorants Cosmetic Preservatives UV Filters & Sunscreen Ingredients Hair Conditioning Ingredients Rheology Modifiers & Thickeners Active Cosmetic Ingredients Plant Extracts & Botanical Ingredients
Regulatory Clusters
Cosmetic Ingredients Flagged as Endocrine Disruptors Cosmetic Ingredients Listed Under California Proposition 65 Cosmetic Ingredients with SCCS Safety Opinions Cosmetic Ingredients with CIR Expert Panel Conclusions Cosmetic Ingredients with GHS Hazard Classification Cosmetic Ingredients with NOAEL Toxicological Data Cosmetic Ingredients Banned or Restricted Globally Cosmetic Ingredients with Sensitization Data Cosmetic Ingredients with Dermal Absorption Data Cosmetic Ingredients Restricted Under EU Regulation 1223/2009
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #
Ingredient Safety EU Status
1,2,4-Benzenetriacetate Poor prohibited
1,2,4-Trihydroxybenzene Poor prohibited
1,3-Bis-(2,4-Diaminophenoxy)Propane Moderate prohibited
1,4-Butanediol Poor restricted
1,5-Dimethylbicyclo[3.2.1]octan-8-one Oxime Good prohibited
1,5-Naphthalenediol Moderate prohibited
1,6-Hexamethylene Diisocyanate (HDI) Poor prohibited
1,6-Hexanediamine Poor prohibited
1,7-Naphthalenediol Moderate prohibited
1-Acetoxy-2-Methylnaphthalene Good restricted
1-Allyl-3,4,6-Trimethyl-2-Pyrimidone Bromide Moderate prohibited
1-Hexyl 4,5-Diamino Pyrazole Sulfate Good restricted
1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate Moderate restricted
1-Methyl-4-methylvinyl-cyclohexene Moderate restricted
1-Naphthol Moderate restricted
1-Nitropropane Poor prohibited
1-Trimethyl-3-Cyclohexenylethanone Moderate prohibited
16-Beta Methyl Estradiolpropanoate Moderate prohibited
2,2'-Methylenebis 4-Aminophenol Moderate restricted
2,2'-Methylenebis-4-Aminophenol HCl Moderate restricted
2,2'-Thiobis(4-Chlorophenol) Poor prohibited
2,3-Butanediol Moderate restricted
2,3-Diaminodihydropyrazolo Pyrazolone Dimethosulfonate Moderate restricted
2,3-Dimethyl-4-formyl-1-phenyl-5-pyrazolone Moderate restricted
2,3-EPOXYPROPYLTRIMONIIUM CHLORIDE Moderate restricted
2,3-Epoxypropyl Cocodimonium Chloride Poor prohibited
2,3-Epoxypropyl Lauryldimonium Chloride Poor prohibited
2,3-Naphthalenediol Poor prohibited
2,4-Diamino-5-methylphenetole HCl Poor prohibited
2,4-Diamino-5-methylphenoxyethanol Moderate restricted
2,4-Diamino-5-methylphenoxyethanol HCl Moderate restricted
2,4-Diaminodiphenylamine Poor prohibited
2,4-Diaminophenol Poor prohibited
2,4-Diaminophenol HCl Poor prohibited
2,4-Diaminophenoxyethanol HCl Moderate restricted
2,4-Diaminophenoxyethanol Sulfate Moderate restricted
2,4-Xylenol Poor prohibited
2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE Moderate restricted
2,6,6-Trimethyl-2-cyclohexene-1-acetaldehyde Good restricted
2,6-Bis(2-Hydroxyethoxy)-3,5-Pyridinediamine HCl Moderate prohibited
2,6-Diamino-3-((Pyridin-3-Yl)Azo)Pyridine Moderate prohibited
2,6-Diaminopyridine Sulfate Poor prohibited
2,6-Diaminopyridine ⚠️ Poor prohibited
2,6-Dihydroxy-3,4-Dimethylpyridine Moderate restricted
2,6-Dihydroxyethylaminotoluene Good prohibited
2,6-Dimethoxy-3,5-Pyridinediamine HCl Moderate restricted
2,6-Dimethyl-p-phenylenediamine Moderate restricted
2,6-Dimethyl-p-phenylenediamine HCl Moderate restricted
2,7-Dimethyl-10-isopropyl-1-oxaspiro-3,6-decadiene Good restricted
2,7-Naphthalenediol Moderate prohibited
2-ACRYLAMIDO-2-METHYLPROPANE SULFONIC ACID Moderate restricted
2-Amino-3-Hydroxypyridine Good restricted
2-Amino-3-Nitrophenol Moderate prohibited
2-Amino-4-Hydroxyethylaminoanisole Moderate prohibited
2-Amino-4-Hydroxyethylaminoanisole Sulfate Moderate prohibited
2-Amino-4-Nitrophenol Moderate prohibited
2-Amino-4-Nitrophenol Sulfate Moderate prohibited
2-Amino-5-Ethylphenol HCl Moderate prohibited
2-Amino-5-Nitrophenol Moderate prohibited
2-Amino-6-Chloro-4-Nitrophenol Moderate prohibited
2-Aminobutanol Good restricted
2-Aminomethyl-P-Aminophenol HCl Poor prohibited
2-BROMO-2-NITROPROPANE-1,3-DIOL Moderate restricted
2-Bromo-2-Nitropropane-1,3-Diol (Bronopol) Moderate restricted
2-Chloro-5-Nitro-N-Hydroxyethyl P-Phenylenediamine Poor prohibited
2-Chloro-6-Ethylamino-4-Nitrophenol Moderate restricted
2-Chloro-P-Phenylenediamine Poor prohibited
2-Chloro-P-Phenylenediamine Sulfate Poor prohibited
2-Decenal Moderate prohibited
2-Ethoxyethanol Poor prohibited
2-Ethylidenedecanal Moderate restricted
2-Hexyloxy-P-Phenylenediamine HCl 🔴 Moderate prohibited
2-Hexyloxycarbonyl-P-Phenylenediamine HCl Moderate prohibited
2-Hydroxyethyl Picramic Acid Good restricted
2-Hydroxyethylamino-5-Nitroanisole Good prohibited
2-Methoxy-4-Methoxymethyl-Phenol Good prohibited
2-Methoxy-p-Phenylenediamine Sulfate Moderate restricted
2-Methoxymethyl-P-Phenylenediamine (ME-PPD) Good prohibited
2-Methoxymethyl-P-Phenylenediamine Sulfate Good prohibited
2-Methoxymethyl-p-Aminophenol HCl Poor prohibited
2-Methoxyphenol/2,2-Dimethyl-3-Methylenebicyclo-Heptane Hydrogenated Moderate prohibited
2-Methyl-1-Naphthol Moderate restricted
2-Methyl-5-Hydroxyethylaminophenol Moderate prohibited
2-Methylbenzoxazole Moderate prohibited
2-Methylbutane-2-Thiol Moderate prohibited
2-Methyldodecanal Moderate restricted
2-Methylfuran-3-Thiol Moderate prohibited
2-Methylnaphthalene Moderate prohibited
2-Methylpent-3-Enoic Acid Good prohibited
2-Methylresorcinol Moderate restricted
2-Methylresorcinol ⭐ (Most extensively assessed) Moderate prohibited
2-NAPHTHOL Moderate restricted
2-Naphthol (β-Naphthol) 🔴 Poor prohibited
2-Nitro-5-Glyceryl Methylaniline Moderate prohibited
2-Nitro-N-Hydroxyethyl-P-Anisidine Moderate prohibited
2-Nitro-P-Phenylenediamine Poor prohibited
2-Nitro-P-Phenylenediamine Dihydrochloride Poor prohibited
2-Nitro-P-Phenylenediamine Sulfate Poor prohibited
2-Sec-Butylcyclohexanone Good prohibited
2-Tert-Butylhydroquinone Methyl Ether Moderate restricted
2-Undecenenitrile Good prohibited
3,4-Diaminobenzoic Acid Poor prohibited
3,4-Methylenedioxyaniline Poor prohibited
3,4-Methylenedioxyphenol Moderate restricted
3,6-Dimethyl-3-Octanol Moderate restricted
3-Amino-2,4-Dichlorophenol Moderate prohibited
3-Amino-2,4-Dichlorophenol HCl Moderate prohibited
3-Amino-2,6-Dimethylphenol Moderate restricted
3-Benzylidene Camphor Poor prohibited
3-Butyl-4-Methylphenyl Methyl Ketone Good prohibited
3-Carene Moderate restricted
3-Ethylamino-P-Cresol Sulfate Moderate prohibited
3-Ethylphenol Moderate restricted
3-Hexyloxycarbonyl-4,4'-Diaminodiphenylamine HCl Moderate prohibited
3-Methoxybutanol Poor prohibited
3-Methyl-1-Phenyl-2-Hexene 1,5-Epoxide Moderate restricted
3-Methyl-1-Phenyl-3-Hexene 1,5-Epoxide Moderate restricted
3-Methyl-4-(3,5,6-Trimethyl-3-Cyclohexenyl)-3-Buten-2-One Good restricted
3-Methyl-5-(2,2,3-Trimethyl-3-Cyclopentenyl)Pent-4-En-2-Ol (Sandalore) Excellent restricted
3-Methyl-5-Phenyl-2-Pentenenitrile (Citrontrile / Citronitrile) Moderate restricted
3-Methylamino-4-Nitrophenoxyethanol Moderate prohibited
3-Methylcyclopentadecanol Moderate prohibited
3-Methylpent-3-En-2-One Moderate prohibited
3-Nitro-4-Aminophenoxyethanol Moderate prohibited
3-Nitro-P-Cresol Moderate prohibited
3-Nitro-P-Hydroxyethylaminophenol Moderate prohibited
3-P-Cumenyl Propionaldehyde Moderate prohibited
3-Propylidenephthalide Good prohibited
4,4'-Diaminodiphenylamine Poor prohibited
4,4'-Diaminodiphenylamine Sulfate Poor prohibited
4,4'-ISOPROPYLIDENEDIPHENOL Moderate restricted
4,4'-Isopropylidenediphenol (Bisphenol A / BPA) Poor prohibited
4,4'-Isopropylidenediphenol/Epichlorohydrin Copolymer Moderate restricted
4,4'-Isopropylidenediphenyl/Epichlorohydrin Copolymer Diacrylate Moderate prohibited
4,5-DIAMINO-1-((4-CHLOROPHENYL)METHYL)-1H-PYRAZOLE-SULFATE Moderate restricted
4,5-Diamino-1-((4-Chlorophenyl)Methyl)-1H-Pyrazole Sulfate Poor prohibited
4,5-Diamino-1-Methylpyrazole HCl Poor prohibited
4,6-Bis(2-Hydroxyethoxy)-M-Phenylenediamine Poor prohibited
4,6-Bis(2-Hydroxyethoxy)-M-Phenylenediamine HCl Poor prohibited
4,8-Dimethyl-4,9-Decadienal Good restricted
4-Amino-2-Hydroxytoluene Moderate prohibited
4-Amino-2-Hydroxytoluene Sulfate Moderate prohibited
4-Amino-2-Nitrodiphenylamine-2'-Carboxylic Acid Moderate prohibited
4-Amino-2-Nitrophenol ⚠️ Poor prohibited
4-Amino-M-Cresol Moderate prohibited
4-Chloro-2-Aminophenol Poor prohibited
4-Chlororesorcinol Moderate prohibited
4-Dimethylmethylenecyclohexyl-Butan-2-One Moderate prohibited
4-Ethoxy-M-Phenylenediamine Poor prohibited
4-Ethoxy-M-Phenylenediamine Sulfate Poor prohibited
4-Ethyl-6-(2,6,6-Trimethyl-2-Cyclohexenyl)-2-Hexene-1,4-Diol Cyclized Good prohibited
4-Ethylresorcinol Moderate prohibited
4-Fluoro-6-Methyl-M-Phenylenediamine Sulfate Moderate prohibited
4-Formyl-1-Methylquinolinium-P-Toluenesulfonate Good prohibited
4-Furanylethyl Resorcinol Moderate prohibited
4-Hydroxybenzoic Acid Excellent restricted
4-Hydroxyindole Poor prohibited
4-Hydroxypropylamino-3-Nitrophenol Good prohibited
4-Isobutylresorcinol Moderate prohibited
4-METHYLBENZYLIDENE CAMPHOR Moderate restricted
4-Methoxytoluene-2,5-Diamine HCl Poor prohibited
4-Methyl-7-Geranyloxycoumarin Moderate prohibited
4-Methylbenzyl 4,5-Diamino Pyrazole Sulfate Moderate prohibited
4-Methylquinoline (Lepidine) Moderate prohibited
4-Nitro-M-Phenylenediamine Poor prohibited
4-Nitro-M-Phenylenediamine Sulfate Poor prohibited
4-Nitro-O-Phenylenediamine Moderate restricted
4-Nitro-O-Phenylenediamine Dihydrochloride Moderate restricted
4-Nitro-O-Phenylenediamine HCl Moderate prohibited
4-Nitro-O-Phenylenediamine Sulfate Moderate prohibited
4-Nitroguaiacol Poor prohibited
4-Nitrophenyl Aminoethylurea Moderate restricted
4-T-Butyl Benzaldehyde Moderate prohibited
4-T-Butyl Styrene Poor prohibited
4-T-Butylbenzoic Acid Poor prohibited
4-T-Butylcyclohexanol Good prohibited
4-TERT-BUTYLDIHYDROCINNAMALDEHYDE Moderate restricted
4-Tert-Butylcyclohexanone Good prohibited
4-Tert-Butyldihydrocinnamaldehyde (Bourgeonal) Moderate prohibited
4-Tert-Butyltoluene Moderate prohibited
4-n-Butylresorcinol Good restricted
5-Amino-2,6-Dimethoxy-3-Hydroxypyridine Moderate restricted
5-Amino-4-Chloro-o-Cresol Moderate restricted
5-Amino-4-Chloro-o-Cresol HCl Moderate prohibited
5-Amino-4-Fluoro-2-Methylphenol Sulfate Poor prohibited
5-Cyclohexadecenone Good restricted
5-Isopropyltropolone Moderate prohibited
6-Amino-2,4-Dichloro-M-Cresol HCl Moderate prohibited
6-Amino-M-Cresol Poor prohibited
6-Amino-O-Cresol Poor prohibited
6-Aminocaproic Acid Moderate prohibited
6-Hydroxyindole Good restricted
7-Amino Dihydrobenzothiazine Moderate prohibited
7-Ethylbicyclooxazolidine Moderate restricted
7-Hydroxy-3,7-Dimethyl-Octanal Distillates Moderate restricted
7-Hydroxy-3,7-Dimethyl-Octanal/Indole Moderate restricted
8-Cyclohexadecenone Good prohibited
8-Hydroxydaidzein Moderate prohibited
9-Decenal Good restricted
9-Decenyl Acetate Good prohibited
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